In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide
chain is contained in multiple gene segments scattered along a chromosome. During the …

The halltnark of the immune response is its specificity and the specificity is directly correlated
with the affinity of the antigen-antibody interaction. The requirement for high affinity …

S107, a phosphocholine-binding myeloma protein, has been cloned in soft agar, and an
antigen-binding variant has been isolated and characterized. The variant does not bind …

Adaptive evolution, to a large extent, is a complex combinatorial optimization process. In this
article we take beginning steps towards developing a general theory of adaptive “walks” via …

All rearranging antigen receptor genes have one or two highly diverse complementarity
determining regions (CDRs) among the six that typically form the ligand binding surface. We …

Adaptive evolution is, to a large extent, a complex combinatorial optimization process. Such
processes can be characterized as “uphill walks on rugged fitness landscapes”. Concrete …

Chimeric genes composed of immunoglobulin (Ig)-derived variable (V) regions and T-cell
receptor (TCR)-derived constant (C) regions were constructed. The VL and VH genes …

We studied the in vivo recombination between homologous DNA sequences cloned in
phage lambda and a pBR322-derived plasmid by assaying for the formation of phage …

Multiple DNA and protein sequence alignments have been constructed for the human T-cell
receptor α/δ, β, and γ (TCRA/D, B, and G) variable (V) gene segments. The traditional …

We present the initial characterization of a novel family of genes that rearrange in T cells, but
do not encode either of the defined (o//3) subunits of the clonespecific heterodimer of the T …