Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …
between innocuous antigens and potential pathogens to maintain oral tolerance. However …
Macrophages and the maintenance of homeostasis
There have been many chapters written about macrophage polarization. These chapters
generally focus on the role of macrophages in orchestrating immune responses by …
generally focus on the role of macrophages in orchestrating immune responses by …
Formation, signaling and occurrence of specialized pro-resolving lipid mediators—what is the evidence so far?
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …
Eicosanoids
PC Calder - Essays in Biochemistry, 2020 - portlandpress.com
This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action
of eicosanoids in different physiological systems, the roles of eicosanoids in selected …
of eicosanoids in different physiological systems, the roles of eicosanoids in selected …
[HTML][HTML] Targeting neutrophils for promoting the resolution of inflammation
JG Filep - Frontiers in immunology, 2022 - frontiersin.org
Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
NK Singh, GN Rao - Progress in lipid research, 2019 - Elsevier
lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …
The resolution of inflammation: Principles and challenges
SE Headland, LV Norling - Seminars in immunology, 2015 - Elsevier
The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …
Resolution of inflammation: an integrated view
A Ortega‐Gómez, M Perretti… - EMBO molecular …, 2013 - embopress.org
Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …
integrity and function. This review integrates the key molecular and cellular mechanisms of …
Annexin A1 and the resolution of inflammation: modulation of neutrophil recruitment, apoptosis, and clearance
MA Sugimoto, JP Vago, MM Teixeira… - Journal of immunology …, 2016 - Wiley Online Library
Neutrophils (also named polymorphonuclear leukocytes or PMN) are essential components
of the immune system, rapidly recruited to sites of inflammation, providing the first line of …
of the immune system, rapidly recruited to sites of inflammation, providing the first line of …
Phagocyte partnership during the onset and resolution of inflammation
O Soehnlein, L Lindbom - Nature Reviews Immunology, 2010 - nature.com
Neutrophils, monocytes and macrophages are closely related phagocytic cells that
cooperate during the onset, progression and resolution of inflammation. This Review …
cooperate during the onset, progression and resolution of inflammation. This Review …