Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

We present a major update of the HOCOMOCO collection that consists of patterns
describing DNA binding specificities for human and mouse transcription factors. In this …

Multiple sclerosis (MS) is a heterogeneous disease where herpesvirus infection and genetic
predisposition are identified as the most consistent risk factors. Serum and blood samples …

Abstract Toll-like receptor 4 (TLR4) is an innate immunity receptor predominantly expressed
on myeloid cells and involved in the development of various diseases, many of them with …

Background: Multiple sclerosis (MS) is a common demyelinating neurodegenerative
disorder with significant heritability. Previous studies have associated genetic variants in …

Background Chronic kidney disease (CKD) disrupts mineral homeostasis and its main
underlying cause is secondary hyperparathyroidism (SHPT). We previously reported that …

Genome-wide association studies have identified more than 200 multiple sclerosis (MS)-
associated loci across the human genome over the last decade, suggesting complexity in …

Pancreatic ductal adenocarcinoma (PDA) is notorious for its poor prognosis. The current
mainstay of treatment for PDA is surgical resection followed by adjuvant chemotherapy …

Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental
condition characterized by challenges with communication, social interaction, and behavior …