Histone acetylation regulates many cellular processes, and specific acetylation marks, either
singly or in combination, produce distinct outcomes. For example, the acetylation pattern on …

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …

Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation
machinery to a highly localized domain at the 5′ portion of active mRNA coding regions …

Covalent modifications of the amino termini of the core histones in nucleosomes have
important roles in gene regulation. Research in the past two years reveals these …

Chromatin is the physiologically relevant substrate for all genetic processes inside the nuclei
of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are …

Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by
targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an …

Sequence analyses of fungal genomes have revealed that the potential of fungi to produce
secondary metabolites is greatly underestimated. In fact, most gene clusters coding for the …

The functions of the SAGA and SWI/SNF complexes are interrelated and can form stable"
epigenetic marks" on promoters in vivo. Here we show that stable promoter occupancy by …

Somatic hypermutation (SHM) introduces mutations in the variable region of
immunoglobulin genes at a rate of∼ 10− 3 mutations per base pair per cell division, which is …

The transcription factor MYC binds specific DNA sites in cellular chromatin and induces the
acetylation of histones H3 and H4. However, the histone acetyltransferases (HATs) that are …