The present review describes available evidence about the fate of micronuclei and
micronucleated cells. Micronuclei are small, extranuclear chromatin bodies surrounded by a …

There have been enough cell death modes delineated in the biomedical literature to
befuddle all cell death researchers. Mulling over cell death from the viewpoints of the host …

Inhibition of the protein kinase WEE1 synergizes with chemotherapy in preclinical models
and WEE1 inhibitors are being explored as potential cancer therapies. Here, we investigate …

Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …

Genome chaos, a process of complex, rapid genome re-organization, results in the
formation of chaotic genomes, which is followed by the potential to establish stable …

The spatial organization of the genome is enigmatic. Direct evidence of physical contacts
between chromosomes and their visualization at nanoscale resolution has been limited. We …

Cells are constantly exposed to various internal and external stresses. The importance of
cellular stress and its implication to disease conditions have become popular research …

The recently introduced genome theory of cancer evolution provides a new framework for
evolutionary studies on cancer. In particular, the established relationship between the large …

Combining cell-cycle checkpoint kinase inhibitors with the DNA-damaging
chemotherapeutic agent gemcitabine offers clinical appeal, with a mechanistic rationale …

In a departure from traditional gene-centric thinking with regard to cytogenetics and
cytogenomics, the recently introduced genome theory calls upon a re-focusing of our …