Biomarkers of sepsis: time for a reappraisal

C Pierrakos, D Velissaris, M Bisdorff, JC Marshall… - Critical Care, 2020 - Springer
Introduction Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic
functions. In a previous review, we identified 3370 references reporting on 178 different …

Notch signaling in acute inflammation and sepsis

N Gallenstein, L Tichy, MA Weigand… - International Journal of …, 2023 - mdpi.com
Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and
homeostasis of immune cells. Besides, this pathway is also directly involved in the …

Notch signaling pathway is activated by sulfate reducing bacteria

SB Singh, CN Coffman, A Carroll-Portillo… - Frontiers in Cellular …, 2021 - frontiersin.org
Sulfate Reducing Bacteria (SRB), usually rare residents of the gut, are often found in
increased numbers (called a SRB bloom) in inflammatory conditions such as Inflammatory …

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

S Rahn, C Becker‐Pauly - FEBS letters, 2022 - Wiley Online Library
Systemic inflammatory disorders (SIDs) comprise a broad range of diseases characterized
by dysregulated excessive innate immune responses. Severe forms of SIDs can lead to …

Notch ligand delta-like 1 is associated with loss of vascular endothelial barrier function

M Moll, K Reichel, D Nurjadi, S Förmer, LJ Krall… - Frontiers in …, 2021 - frontiersin.org
Vascular leakage associated with vascular endothelial cell (vEC) dysfunction is a hallmark
of sepsis. Causative for the decreased integrity of the vascular endothelium (vE) is a …

Sepsis-induced myopathy and gut microbiome dysbiosis: mechanistic links and therapeutic targets

RT Mankowski, O Laitano, D Darden, L Kelly, J Munley… - Shock, 2022 - journals.lww.com
Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection. The skeletal muscle system is among the host organ systems …

A review of natural therapies potentially relevant in triple negative breast cancer aimed at targeting cancer cell vulnerabilities

MJ Webb, C Kukard - Integrative Cancer Therapies, 2020 - journals.sagepub.com
We reviewed the research into the mechanisms of growth of triple negative breast cancer
(TNBC) based on laboratory pre-clinical studies that have shaped understanding of the …

Evaluation of the Novel Sepsis Biomarker Host-Derived Delta-like Canonical Notch Ligand 1—A Secondary Analysis of 405 Patients Suffering from Inflammatory or …

T Hölle, P Rehn, K Leventogiannis, A Kotsaki… - International Journal of …, 2023 - mdpi.com
Sepsis is defined as organ failure caused by dysregulated host response to infection. While
early antibiotic treatment in patients with acute infection is essential, treating non-infectious …

Machine learning identification of specific changes in myeloid cell phenotype during bloodstream infections

C Gosset, J Foguenne, M Simul, O Tomsin, H Ammar… - Scientific Reports, 2021 - nature.com
The early identification of bacteremia is critical for ensuring appropriate treatment of
nosocomial infections in intensive care unit (ICU) patients. The aim of this study was to use …

Delta 样配体1 水平对脓毒症患者病情危险分层及预后的评估价值

刘梦梦, 乔淑斐, 苏燕, 崔业惠, 李燕 - 临床急诊杂志, 2024 - whuhzzs.com
目的探讨血浆Delta 样配体1 (Delta-like ligand 1, DLL1) 水平在判断脓毒症患者疾病严重程度及
预后价值中的作用. 方法收集86 例脓毒症患者的临床资料, 根据入院后患者的病情严重程度分为 …