Layered mechanisms regulating the human mitochondrial NAD+ transporter SLC25A51
S Goyal, XA Cambronne - Biochemical Society Transactions, 2023 - portlandpress.com
SLC25A51 is the primary mitochondrial NAD+ transporter in humans and controls many
local reactions by mediating the influx of oxidized NAD+. Intriguingly, SLC25A51 lacks …
local reactions by mediating the influx of oxidized NAD+. Intriguingly, SLC25A51 lacks …
The effects of cardiolipin on the structural dynamics of the mitochondrial ADP/ATP carrier in its cytosol-open state
Q Yi, S Yao, B Ma, X Cang - Journal of Lipid Research, 2022 - ASBMB
Cardiolipin (CL) has been shown to play a crucial role in regulating the function of proteins
in the inner mitochondrial membrane. As the most abundant protein of the inner …
in the inner mitochondrial membrane. As the most abundant protein of the inner …
Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier
Lipid-protein interactions play a multitude of essential roles in membrane homeostasis.
Mitochondrial membranes have a unique lipid-protein environment that ensures …
Mitochondrial membranes have a unique lipid-protein environment that ensures …
New insights into the evolution and gene structure of the mitochondrial carrier family unveiled by analyzing the frequent and conserved intron positions
Mitochondrial carriers (MCs) belong to a eukaryotic protein family of transporters that in
higher organisms is called the solute carrier family 25 (SLC25). All MCs have characteristic …
higher organisms is called the solute carrier family 25 (SLC25). All MCs have characteristic …
[HTML][HTML] Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant
The mitochondrial phospholipid cardiolipin (CL) promotes bioenergetics via oxidative
phosphorylation (OXPHOS). Three tightly bound CLs are evolutionarily conserved in the …
phosphorylation (OXPHOS). Three tightly bound CLs are evolutionarily conserved in the …
Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations
The mitochondrial ADP/ATP carrier (AAC) exports ATP and imports ADP through alternating
between cytosol-open (c-) and matrix-open (m-) states. The salt bridge networks near the …
between cytosol-open (c-) and matrix-open (m-) states. The salt bridge networks near the …