The emerging roles of circRNAs in cancer and oncology

LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

The biogenesis, biology and characterization of circular RNAs

LS Kristensen, MS Andersen, LVW Stagsted… - Nature reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …

Translation and functional roles of circular RNAs in human cancer

M Lei, G Zheng, Q Ning, J Zheng, D Dong - Molecular cancer, 2020 - Springer
Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed
loops through backsplicing. Recent methodologies have enabled in-depth characterization …

Past, present, and future of circ RNA s

IL Patop, S Wüst, S Kadener - The EMBO journal, 2019 - embopress.org
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of …

Circular RNAs in cancer: biogenesis, function, and clinical significance

J Li, D Sun, W Pu, J Wang, Y Peng - Trends in cancer, 2020 - cell.com
Circular RNA (circRNA) is a class of single-stranded molecules with tissue/development-
specific expression patterns. Unlike linear RNA, circRNA forms a covalently closed loop …

Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer

X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …

Circular RNAs act as miRNA sponges

AC Panda - Circular RNAs: biogenesis and functions, 2018 - Springer
Majority of RNAs expressed in animal cells lack protein-coding ability. Unlike other cellular
RNAs, circular (circ) RNAs include a large family of noncoding (nc) RNAs that lack the 5′ or …

The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway

X Zhang, S Wang, H Wang, J Cao, X Huang, Z Chen… - Molecular cancer, 2019 - Springer
Background CircRNA has emerged as a new non-coding RNA that plays crucial roles in
tumour initiation and development.'MiRNA sponge'is the most reported role played by …