The principles of directed cell migration

S SenGupta, CA Parent, JE Bear - Nature Reviews Molecular Cell …, 2021 - nature.com
Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury

G Nocera, C Jacob - Cellular and Molecular Life Sciences, 2020 - Springer
The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous
system (PNS), is a critical feature in the context of peripheral nerve regeneration following …

The endothelium–bone axis in development, homeostasis and bone and joint disease

J Tuckermann, RH Adams - Nature Reviews Rheumatology, 2021 - nature.com
Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Understanding axon guidance: are we nearly there yet?

ET Stoeckli - Development, 2018 - journals.biologists.com
During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

Targeting skeletal endothelium to ameliorate bone loss

R Xu, A Yallowitz, A Qin, Z Wu, DY Shin, JM Kim… - Nature medicine, 2018 - nature.com
Recent studies have identified a specialized subset of CD31hiendomucinhi
(CD31hiEMCNhi) vascular endothelium that positively regulates bone formation. However, it …

Neuroblastoma—a neural crest derived embryonal malignancy

JI Johnsen, C Dyberg, M Wickström - Frontiers in molecular …, 2019 - frontiersin.org
Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …

Single-cell connectomic analysis of adult mammalian lungs

MSB Raredon, TS Adams, Y Suhail, JC Schupp… - Science …, 2019 - science.org
Efforts to decipher chronic lung disease and to reconstitute functional lung tissue through
regenerative medicine have been hampered by an incomplete understanding of cell-cell …

Congenital diaphragmatic hernias: from genes to mechanisms to therapies

G Kardon, KG Ackerman, DJ McCulley… - Disease models & …, 2017 - journals.biologists.com
Congenital diaphragmatic hernias (CDHs) and structural anomalies of the diaphragm are a
common class of congenital birth defects that are associated with significant morbidity and …

Motivating role of type H vessels in bone regeneration

J Zhang, J Pan, W Jing - Cell proliferation, 2020 - Wiley Online Library
Coupling between angiogenesis and osteogenesis has an important role in both normal
bone injury repair and successful application of tissue‐engineered bone for bone defect …

SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia

LH Geraldo, Y Xu, L Jacob… - The Journal of …, 2021 - Am Soc Clin Investig
SLIT2 is a secreted polypeptide that guides migration of cells expressing Roundabout 1 and
2 (ROBO1 and ROBO2) receptors. Herein, we investigated SLIT2/ROBO signaling effects in …