Immune checkpoint blockade therapy targeting programmed cell death protein 1 (PD-1) has
revolutionized the landscape of multiple human cancer types, including head and neck …

Highlights•Mast cells and basophils have similar morphological characteristics and express
the high-affinity FceRI on their cell surface.•Genetically engineered deletion mice …

Fungi are abundant in the environment, causing our lungs to be constantly exposed to a
diverse range of species. While the majority of these are cleared effectively in healthy …

Urinary tract infections (UTIs) typically evoke prompt and vigorous innate bladder immune
responses, including extensive exfoliation of the epithelium. To explain the basis for the …

The worldwide prevalence of asthma and allergic disorders (allergic rhinitis, atopic
dermatitis, food allergy) has been steadily rising in recent decades. It is now estimated that …

House dust mites (HDMs) are sources of an extensive repertoire of allergens responsible for
a range of allergic conditions. Technological advances have accelerated the identification of …

This review summarizes some of the most significant advances in asthma research over the
past year. We first focus on novel discoveries in the mechanism of asthma development and …

Proteinases are essential drivers of allergic airway disease and innate antifungal immunity
in part through their ability cleave the clotting factor fibrinogen (FBG) into fibrinogen …

Upon encountering allergens, CD4+ T cells differentiate into IL-4-producing Th2 cells in
lymph nodes, which later transform into polyfunctional Th2 cells producing IL-5 and IL-13 in …

Serodominant group 1 allergens of house dust mites (HDMs) are cysteine protease
digestive enzymes. By increasing the detection of any allergen by dendritic antigen …