ABSTRACT Preclinical Research MicroRNAs (miRNAs) are small endogenous noncoding
RNAs that suppress gene expression at the post‐transcriptional level. In the past decade …

Interferons (IFNs) elicit multifaceted effects in host innate defence. Accumulating evidence
revealed that not only the first identified Jak‐Stat pathway but also other newly found …

The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular
functions. The major signaling pathway activated by type I IFNs involves sequential …

To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2-/-
mice. In contrast to other Jaks, where inactivation leads to a complete loss of the respective …

Type I interferons (IFNα/β) induce antiviral responses and have immunomodulatory effects
that can either promote or suppress immunity and inflammation. In myeloid cells IFNα/β …

Activation of cytosolic phospholipase A 2 (cPLA 2) is a prerequisite for the formation of the
transcription factor complex interferon‐stimulated gene factor 3 (ISGF3) in response to …

Measles virus, a paramyxovirus of the Morbillivirus genus, is responsible for an acute
childhood illness that infects over 40 million people and leads to the deaths of more than 1 …

The signal transducer and activator of transcription (STAT) 3, a transcriptional factor
downstream of several cytokines, is activated by Janus kinase families and plays a pivotal …

The nuclear factor κB (NF-κB) transcription factor regulates the expression of genes involved
in cell survival and immune responses. We have identified a novel interferon (IFN)-activated …

Interferons are pleiotropic cytokines that exhibit negative regulatory effects on the growth of
normal and malignant hematopoietic cells in vitro and in vivo. There are two different classes …