The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

The liver is the center for drug and xenobiotic metabolism, which is influenced most with
medication/xenobiotic-mediated toxic activity. Drug-induced hepatotoxicity is common and …

Botanicals have been used traditionally by herbalists and indigenous healers worldwide for
the prevention and treatment of liver disease. Clinical research in this century has confirmed …

The flavonoid silymarin and one of its structural components, silibinin, are substances with
documented hepatoprotective properties. Their mechanisms of action are still poorly …

Background: Amatoxin poisoning is a medical emergency characterized by a long
incubation time lag, gastrointestinal and hepatotoxic phases, coma, and death. This …

The mechanisms of action of silymarin involve different biochemical events, such as the
stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of …

Ethnopharmacological relevance Silybum marianum (L.) Gaertn. or Milk thistle is a
medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. It …

Over the last 10 years, a significant body of evidence has emerged indicating that chemically
diverse classes of naturally-occurring substances derived from higher plants are of potential …

Silymarin is a polyphenolic flavonoid derived from milk thistle (Silybum marianum) that has
anti-inflammatory, cytoprotective, and anticarcinogenic effects. How silymarin produces …

Silymarin consists of a family of flavonoids (silybin, isosilybin, silychristin, silydianin and
taxifoline) commonly found in the dried fruit of the milk thistle plant Silybum marianum …