M2 macrophage polarization: A potential target in pain relief
W Zhao, L Ma, D Deng, T Zhang, L Han, F Xu… - Frontiers in …, 2023 - frontiersin.org
Pain imposes a significant urden on patients, affecting them physically, psychologically, and
economically. Despite numerous studies on the pathogenesis of pain, its clinical …
economically. Despite numerous studies on the pathogenesis of pain, its clinical …
Crosstalk Among Glial Cells in the Blood–Brain Barrier Injury After Ischemic Stroke
W Lu, J Wen - Molecular Neurobiology, 2024 - Springer
Blood–brain barrier (BBB) is comprised of brain microvascular endothelial cells (ECs),
astrocytes, perivascular microglia, pericytes, neuronal processes, and the basal lamina. As a …
astrocytes, perivascular microglia, pericytes, neuronal processes, and the basal lamina. As a …
ATG5 knockdown attenuates ischemia‒reperfusion injury by reducing excessive autophagy-induced ferroptosis
Autophagy has been described to be both protective and pathogenic in cerebral
ischemia/reperfusion (I/R) injury. The underlying association between autophagy and …
ischemia/reperfusion (I/R) injury. The underlying association between autophagy and …
[HTML][HTML] Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/SMADs signaling …
J Liao, M Wei, J Wang, J Zeng, D Liu, Q Du, J Ge… - Biomedicine & …, 2023 - Elsevier
Background Cerebral ischemia-reperfusion injury (CIRI), a subsequent injury caused by
thrombolytic reperfusion post ischemic stroke (IS). Naotaifang (NTF) formula, a novel …
thrombolytic reperfusion post ischemic stroke (IS). Naotaifang (NTF) formula, a novel …
TGN-020 Alleviate Inflammation and Apoptosis After Cerebral Ischemia–Reperfusion Injury in Mice Through Glymphatic and ERK1/2 Signaling Pathway
X Li, Z Xie, Q Zhou, X Tan, W Meng, Y Pang… - Molecular …, 2024 - Springer
Post-stroke acute inhibition of aquaporin 4 (AQP4) is known to exacerbate inflammation and
apoptosis, yet the underlying mechanisms are not fully understood. The objective of this …
apoptosis, yet the underlying mechanisms are not fully understood. The objective of this …
Gastrodin against oxidative stress-inflammation crosstalk via inhibiting mtDNA/TLR9 and JAK2/STAT3 signaling to ameliorate ischemic stroke injury
M Zhang, Y Zhang, J Peng, Y Huang, Z Gong… - International …, 2024 - Elsevier
The pathway of Janus-activated kinase 2 (JAK2) and signal transducer and activator of
transcription 3 (STAT3)(termed as JAK2/STAT3) plays an active role in stroke-related …
transcription 3 (STAT3)(termed as JAK2/STAT3) plays an active role in stroke-related …
Exercise improves cerebral blood flow and functional outcomes in an experimental mouse model of vascular cognitive impairment and dementia (VCID)
MB Khan, H Alam, S Siddiqui, MF Shaikh… - Translational Stroke …, 2024 - Springer
Vascular cognitive impairment and dementia (VCID) are a growing threat to public health
without any known treatment. The bilateral common carotid artery stenosis (BCAS) mouse …
without any known treatment. The bilateral common carotid artery stenosis (BCAS) mouse …
Gastric cancer cell-derived exosomal miR-541-5p induces M2 macrophage polarization through DUSP3/JAK2/STAT3 pathway
H Xiao, J Fu, R Liu, L Yan, Z Zhou, J Yuan - BMC cancer, 2024 - Springer
Purpose Exosomal microRNAs have been identified as important mediators of
communication between tumor cells and macrophages in the microenvironment. miR-541 …
communication between tumor cells and macrophages in the microenvironment. miR-541 …
The Phytochemical Agathisflavone Modulates miR146a and miR155 in Activated Microglia Involving STAT3 Signaling
BL Dos Santos, CC Dos Santos, KC da Silva… - International Journal of …, 2024 - mdpi.com
MicroRNAs (miRs) act as important post-transcriptional regulators of gene expression in
glial cells and have been shown to be involved in the pathogenesis of neurodegenerative …
glial cells and have been shown to be involved in the pathogenesis of neurodegenerative …
[HTML][HTML] The Role of Microglia in Brain Metastases: Mechanisms and Strategies
Y Feng, X Hu, Y Zhang, Y Wang - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Brain metastases and related complications are one of the major fatal factors in cancer.
Patients with breast cancer, lung cancer, and melanoma are at a high risk of developing …
Patients with breast cancer, lung cancer, and melanoma are at a high risk of developing …