Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO-1 pathway

R Lv, L Du, L Zhang, Z Zhang - Life sciences, 2019 - Elsevier
Aims Spinal cord injury (SCI) is one of the most devastating central lesions, resulting in
serious locomotor deficit. Polydatin is a glucoside of resveratrol with proven anti …

MCC950, a selective inhibitor of NLRP3 inflammasome, reduces the inflammatory response and improves neurological outcomes in mice model of spinal cord injury

J Jiao, G Zhao, Y Wang, P Ren, M Wu - Frontiers in molecular …, 2020 - frontiersin.org
Spinal cord injury (SCI) is a serious condition that affects bodily function; however, there is
no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 …

Methane ameliorates spinal cord ischemia-reperfusion injury in rats: antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation

L Wang, Y Yao, R He, Y Meng, N Li, D Zhang… - Free Radical Biology …, 2017 - Elsevier
Methane is reported to have antioxidant, anti-inflammatory and anti-apoptotic properties. We
investigated the potential neuroprotective effects of methane-rich saline (MS) on spinal cord …

Hyperbaric oxygen preconditioning attenuates early apoptosis after spinal cord ischemia in rats

L Wang, W Li, Z Kang, Y Liu, X Deng, H Tao… - Journal of …, 2009 - liebertpub.com
This study tested the hypothesis that spinal cord ischemic tolerance induced by hyperbaric
oxygen preconditioning (HBO-PC) is mediated by inhibition of early apoptosis. Male …

Therapeutic potential of berries in age-related neurological disorders

N Norouzkhani, S Afshari, SF Sadatmadani… - Frontiers in …, 2024 - frontiersin.org
Aging significantly impacts several age-related neurological problems, such as stroke, brain
tumors, oxidative stress, neurodegenerative diseases (Alzheimer's, Parkinson's, and …

Carbon monoxide-releasing molecule-3 protects against cortical pyroptosis induced by hemorrhagic shock and resuscitation via mitochondrial regulation

LM Zhang, DX Zhang, L Fu, Y Li, XP Wang… - Free Radical Biology …, 2019 - Elsevier
Objective Carbon monoxide (CO) releasing molecule (CORM)-3, a water-soluble CORM,
has protective effects against inflammatory and ischemia/reperfusion injury. We determined …

Ventilation with argon improves survival with good neurological recovery after prolonged untreated cardiac arrest in pigs

F Fumagalli, D Olivari, A Boccardo… - Journal of the …, 2020 - Am Heart Assoc
Background Ventilation with the noble gas argon (Ar) has shown neuroprotective and
cardioprotective properties in different in vitro and in vivo models. Hence, the …

A systematic review of neuroprotective strategies during hypovolemia and hemorrhagic shock

M Nistor, W Behringer, M Schmidt… - International journal of …, 2017 - mdpi.com
Severe trauma constitutes a major cause of death and disability, especially in younger
patients. The cerebral autoregulatory capacity only protects the brain to a certain extent in …

Postresuscitation treatment with argon improves early neurological recovery in a porcine model of cardiac arrest

G Ristagno, F Fumagalli, I Russo, S Tantillo, DD Zani… - Shock, 2014 - journals.lww.com
Methods The left anterior descending coronary artery was occluded in 12 pigs, and CA was
induced. After 8 min of untreated CA, cardiopulmonary resuscitation was performed for 5 min …

Dynamic regional changes of extracellular ascorbic acid during global cerebral ischemia: Studied with in vivo microdialysis coupled with on-line electrochemical …

K Liu, Y Lin, P Yu, L Mao - Brain Research, 2009 - Elsevier
The morphologic and functional outcomes of cerebral ischemia generally result from the
acute neurochemical changes that occur 1 h after cerebral ischemia. As one of the small …