MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease

M Eslam, AJ Sanyal, J George, A Sanyal… - Gastroenterology, 2020 - Elsevier
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the
population, and has no approved drug therapy. Although pharmacotherapies are in …

Non-alcoholic fatty liver disease: metabolic, genetic, epigenetic and environmental risk factors

O Juanola, S Martínez-López, R Francés… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …

Triggering and resolution of inflammation in NASH

S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …

Genetics and epigenetics of NAFLD and NASH: Clinical impact

M Eslam, L Valenti, S Romeo - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …

NAFLD in children: new genes, new diagnostic modalities and new drugs

V Nobili, A Alisi, L Valenti, L Miele… - Nature reviews …, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) has rapidly become the most common form of
chronic liver disease in children and adolescents. Over the past 5 years, developments have …

[PDF][PDF] The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

J Boursier, O Mueller, M Barret, M Machado… - …, 2016 - Wiley Online Library
Several animal studies have emphasized the role of gut microbiota in nonalcoholic fatty liver
disease (NAFLD). However, data about gut dysbiosis in human NAFLD remain scarce in the …

Nonalcoholic fatty liver disease

EM Brunt, VWS Wong, V Nobili, CP Day… - Nature reviews Disease …, 2015 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation
of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are …

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease

N Fujiwara, N Kubota, E Crouchet, B Koneru… - Science translational …, 2022 - science.org
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with
nonalcoholic fatty liver disease (NAFLD). In cohorts of 409 patients with NAFLD from …

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)

S Wang, SL Friedman - Science translational medicine, 2023 - science.org
Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

Nonalcoholic fatty liver disease: pathogenesis and disease spectrum

T Hardy, F Oakley, QM Anstee… - Annual review of …, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …