Nucleosome structure and dynamics are coming of age
Since the first high-resolution structure of the nucleosome was reported in 1997, the
available information on chromatin structure has increased very rapidly. Here, we review …
available information on chromatin structure has increased very rapidly. Here, we review …
The histone variant H2A. Z in gene regulation
BD Giaimo, F Ferrante, A Herchenröther, SB Hake… - Epigenetics & …, 2019 - Springer
The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
Structure of nucleosome-bound human BAF complex
Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …
Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
A structural model of the endogenous human BAF complex informs disease mechanisms
Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that
regulate genomic architecture. Here, we present a structural model of the endogenously …
regulate genomic architecture. Here, we present a structural model of the endogenously …
Principles of nucleosome recognition by chromatin factors and enzymes
RK McGinty, S Tan - Current Opinion in Structural Biology, 2021 - Elsevier
The recent torrent of structures of chromatin complexes determined by cryoelectron
microscopy provides an opportunity to discern general principles for how chromatin factors …
microscopy provides an opportunity to discern general principles for how chromatin factors …
Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility
Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can
form during transcription. Why INO80 prefers hexasomes over nucleosomes remains …
form during transcription. Why INO80 prefers hexasomes over nucleosomes remains …
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
The chromatin-remodelling complex SWI/SNF is highly conserved and has critical roles in
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
Molecular complexes at euchromatin, heterochromatin and centromeric chromatin
O Morrison, J Thakur - International Journal of Molecular Sciences, 2021 - mdpi.com
Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …
plays an important role in both packaging DNA and regulating DNA metabolic pathways …
Structure and function of chromatin remodelers
AA Reyes, RD Marcum, Y He - Journal of molecular biology, 2021 - Elsevier
Chromatin remodelers act to regulate multiple cellular processes, such as transcription and
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …