Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

The effects of adipocytes on the regulation of breast cancer in the tumor microenvironment: an update

DT Chu, T Nguyen Thi Phuong, NLB Tien, DK Tran… - Cells, 2019 - mdpi.com
Obesity is a global pandemic and it is well evident that obesity is associated with the
development of many disorders including many cancer types. Breast cancer is one of that …

SLC7A11/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells

P Yadav, P Sharma, S Sundaram, G Venkatraman… - Cancer letters, 2021 - Elsevier
Breast cancer cells evade cell death by overexpressing SLC7A11, which functions by
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …

Peptide-based vaccines in clinical phases and new potential therapeutic targets as a new approach for breast cancer: a review

ML Nicolas-Morales, A Luisa-Sanjuan… - Vaccines, 2022 - mdpi.com
Breast cancer is the leading cause of death in women from 20 to 59 years old. The
conventional treatment includes surgery, chemotherapy, hormonal therapy, and …

Current trends on surface acoustic wave biosensors

SI Zida, YD Lin, YL Khung - Advanced Materials Technologies, 2021 - Wiley Online Library
The development of rapid biosensing platforms is an integral part for the detection of many
diseases, as well as important clinical biomarkers. So far, many new biosensing …

Multi-omics approach points to the importance of oxylipins metabolism in early-stage breast cancer

DV Chistyakov, MV Guryleva, ES Stepanova… - Cancers, 2022 - mdpi.com
Simple Summary On a system level, multi-omics approaches allow studying oxylipins,
metabolites of omega-3 or omega-6 polyunsaturated fatty acids. We compared the ultra-high …

Impact of COVID-19 on cancer screening: A global perspective

L Allahqoli, A Mazidimoradi, H Salehiniya… - Current Opinion in …, 2022 - journals.lww.com
Screenings for all types of cancer fell sharply. In the chain of cancer management, delays in
any step are liable to change the outcome of the next step. Further long-term research will …

Genetically engineered pigs to study cancer

D Kalla, A Kind, A Schnieke - International journal of molecular sciences, 2020 - mdpi.com
Recent decades have seen groundbreaking advances in cancer research. Genetically
engineered animal models, mainly in mice, have contributed to a better understanding of the …

Screening of BRCA1/2 genes mutations and copy number variations in patients with high risk for hereditary breast and ovarian cancer syndrome (HBOC)

FZ El Ansari, F Jouali, N Marchoudi, MM Bennani… - BMC cancer, 2020 - Springer
Background Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant
inherited cancer susceptibility disorder. Both BRCA1 and BRCA2 genes are considered as …

The unique biology behind the early onset of breast cancer

A Siddig, TADAA Tengku Din, SN Mohd Nafi… - Genes, 2021 - mdpi.com
Breast cancer commonly affects women of older age; however, in developing countries, up
to 20% of breast cancer cases present in young women (younger than 40 years as defined …