The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

Processed electroencephalogram and evoked potential techniques for amelioration of postoperative delirium and cognitive dysfunction following non‐cardiac and non …

Y Punjasawadwong, W Chau‐in… - Cochrane Database …, 2018 - cochranelibrary.com
Background Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD)
may complicate a patient's postoperative recovery in several ways. Monitoring of processed …

[HTML][HTML] Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice

X Feng, M Valdearcos, Y Uchida, D Lutrin, M Maze… - JCI insight, 2017 - ncbi.nlm.nih.gov
Surgery can induce cognitive decline, a risk that increases with advancing age. In rodents,
postoperative cognitive decline (POCD) is associated with the inflammatory activation of …

[HTML][HTML] Neuroinflammation-mediated mitochondrial dysregulation involved in postoperative cognitive dysfunction

Y Yang, Y Liu, J Zhu, S Song, Y Huang… - Free Radical Biology …, 2022 - Elsevier
Neuroinflammation following peripheral surgery is a pivotal pathogenic mechanism of
postoperative cognitive dysfunction (POCD). However, the key site of inflammation-mediated …

Does general anesthesia affect neurodevelopment in infants and children?

ME McCann, SG Soriano - Bmj, 2019 - bmj.com
General anesthesia has been unequivocally linked to abnormal development of the central
nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in …

Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery

J Hirsch, S Vacas, N Terrando, M Yuan… - Journal of …, 2016 - Springer
Background Postoperative delirium is prevalent in older patients and associated with worse
outcomes. Recent data in animal studies demonstrate increases in inflammatory markers in …

Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction

X Tan, LL Qiu, J Sun - BioMed research international, 2021 - Wiley Online Library
Postoperative cognitive dysfunction (POCD), as one of the common postoperative
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation

AL Luo, J Yan, XL Tang, YL Zhao, BY Zhou… - Inflammopharmacology, 2019 - Springer
The aging population is burgeoning globally and this trend presents great challenges to the
current healthcare system as the growing number of aged individuals receives procedures …

Perioperative brain health in the older adult: a patient safety imperative

S Vacas, C Canales, SG Deiner… - Anesthesia & Analgesia, 2022 - journals.lww.com
While people 65 years of age and older represent 16% of the population in the United
States, they account for> 40% of surgical procedures performed each year. Maintaining …

Challenges in postdischarge function and recovery: the case of fast-track hip and knee arthroplasty

EK Aasvang, IE Luna, H Kehlet - BJA: British Journal of …, 2015 - academic.oup.com
This narrative review updates the recent advances in our understanding of the multifactorial
pathogenesis for reduced postdischarge physical and cognitive function after fast-track …