CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …

The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

As acute infections resolve, effector CD8+ T cells differentiate into interleukin-7 receptor lo
(IL-7R lo) short-lived effector cells (SLECs) and IL-7R hi memory precursor effector cells …

CD25, the high-affinity interleukin-2 (IL-2) receptor α chain, is rapidly upregulated by antigen-
specific CD8+ T cells after T cell receptor stimulation. Here, we demonstrate that during an …

An important question in memory development is understanding the differences between
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells …

Activation of naive CD8+ T cells with antigen induces their differentiation into effector
cytolytic T lymphocytes (CTLs). CTLs lyse infected or aberrant target cells by exocytosis of …

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …

The world is now experiencing an epidemic of obesity. Although the effects of obesity on the
development of metabolic and cardiovascular problems are well studied, much less is …

In the 18th century, Thomas Bayes developed his eponymous theorem that teaches us that
pretest probabilities can be altered by new information, such as when game show host …

The immune system protects us from pathogens, such as viruses. Antiviral immune
mechanisms aim to limit viral replication, and must maintain immunological homeostasis to …