Defects of mitochondrial metabolism cause a wide range of human diseases that include
examples from all medical subspecialties. This review updates the topic of mitochondrial …

Maintenance of proper “labile iron” levels is a critical component in preserving homeostasis.
Iron is a vital element that is a constituent of a number of important macromolecules …

Cardiac failure is the most common cause of mortality in Friedreich's ataxia (FRDA), a
mitochondrial disease characterized by neurodegeneration, hypertrophic cardiomyopathy …

Iron–sulphur clusters are important cofactors for proteins that are involved in many cellular
processes, including electron transport, enzymatic catalysis and regulation. The enzymes …

Friedreich ataxia (FRDA) is caused by a homozygous GAA repeat expansion mutation within
intron 1 of the FXN gene, leading to reduced expression of frataxin protein. Evidence …

Among the hereditary ataxias, autosomal recessive spinocerebellar ataxias comprise a
diverse group of neurodegenerative disorders. Clinical phenotypes vary from predominantly …

Background Friedreich's ataxia (FA) is a progressive, multisystem, degenerative disorder
caused by a reduction in frataxin. Loss of frataxin results in mitochondrial dysfunction and …

Excessive body iron or iron overload occurs under conditions such as primary (hereditary)
hemochromatosis and secondary iron overload (hemosiderosis), which are reaching …

Friedreich ataxia (FRDA) is a neurodegenerative disorder caused by an unstable GAA
repeat expansion mutation within intron 1 of the FXN gene. However, the origins of the GAA …

Embracing both the art and science of skin care, Cosmetic Dermatology covers a wide range
of interventions and treatments designed to maintain and beautify healthy skin and protect …