Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are
important to develop more targeted and effective strategies to prevent suicide. In the last …

Depression is the leading cause of disability around the world, but little is known about its
pathology. Currently, the diagnosis of depression is made based on clinical manifestations …

Objective Amongst psychiatric disorders, major depressive disorder (MDD) is the most
prevalent, by affecting approximately 15–17% of the population and showing a high suicide …

The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …

The stress–diathesis model posits that suicide is the result of an interaction between state-
dependent (environmental) stressors and a trait-like diathesis or susceptibility to suicidal …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Abstract Purpose of Review The rising suicide rate in the USA will not be reversed without
improved risk assessment and prevention practices. To date, the best method for clinicians …

Importance Dysfunctional reward processing is a leading candidate mechanism for the
development of certain depressive symptoms, such as anhedonia. However, to our …

Suicidality is exceedingly prevalent in pain patients. Although the pathophysiology of this
link remains unclear, it may be potentially related to the partial congruence of physical and …

In modern society, depression is one of the most common mental illness; however, its
pathophysiology is not yet fully understood. A great body of evidence suggests that …