Safety, tolerability, and efficacy of repeated doses of dihydroartemisinin-piperaquine for prevention and treatment of malaria: a systematic review and meta-analysis
Background Intermittent preventive treatment (IPT) for malaria is used in infants, children,
adults, and pregnant women. Dihydroartemisinin-piperaquine (DP) is an effective, well …
adults, and pregnant women. Dihydroartemisinin-piperaquine (DP) is an effective, well …
Therapeutical utilization and repurposing of artemisinin and its derivatives: a narrative review
Artemisinin (ART) and its derivatives have great therapeutical utility as antimalarials and can
be repurposed for other indications, such as viral infections, autoimmune diseases, and …
be repurposed for other indications, such as viral infections, autoimmune diseases, and …
Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities
Tools to reliably measure Plasmodium falciparum (Pf) exposure in individuals and
communities are needed to guide and evaluate malaria control interventions. Serologic …
communities are needed to guide and evaluate malaria control interventions. Serologic …
Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children
The emergence of resistance to artemisinin derivatives in Southeast Asia, manifested as
delayed clearance of Plasmodium falciparum following treatment with artemisinins, is a …
delayed clearance of Plasmodium falciparum following treatment with artemisinins, is a …
Loss and dysfunction of Vδ2+ γδ T cells are associated with clinical tolerance to malaria
Although clinical immunity to malaria eventually develops among children living in endemic
settings, the underlying immunologic mechanisms are not known. The Vδ2+ subset of γδ T …
settings, the underlying immunologic mechanisms are not known. The Vδ2+ subset of γδ T …
Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis
LC Okell, M Cairns, JT Griffin, NM Ferguson… - Nature …, 2014 - nature.com
There are currently several recommended drug regimens for uncomplicated falciparum
malaria in Africa. Each has different properties that determine its impact on disease burden …
malaria in Africa. Each has different properties that determine its impact on disease burden …
Comparative Impacts Over 5 Years of Artemisinin-Based Combination Therapies on Plasmodium falciparum Polymorphisms That Modulate Drug Sensitivity in …
MD Conrad, N LeClair, E Arinaitwe… - The Journal of …, 2014 - academic.oup.com
Background. Artemisinin-based combination therapies, including artemether-lumefantrine
(AL) and dihydroartemisinin-piperaquine (DP), are recommended to treat uncomplicated …
(AL) and dihydroartemisinin-piperaquine (DP), are recommended to treat uncomplicated …
Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania
MA Kakolwa, MK Mahende, DS Ishengoma… - Malaria journal, 2018 - Springer
Background Artemisinin-based combination therapy (ACT) is the first-line anti-malarial
treatment of uncomplicated malaria in most malaria endemic countries, including Tanzania …
treatment of uncomplicated malaria in most malaria endemic countries, including Tanzania …
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from Ugandan children
P Tumwebaze, MD Conrad, A Walakira… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Changing treatment practices may be selecting for changes in the drug sensitivity of malaria
parasites. We characterized ex vivo drug sensitivity and parasite polymorphisms associated …
parasites. We characterized ex vivo drug sensitivity and parasite polymorphisms associated …
Comparative efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Ugandan children
A Yeka, E Wallender, R Mulebeke… - The Journal of …, 2019 - academic.oup.com
Abstract Background In Uganda, artemether-lumefantrine (AL) and dihydroartemisinin-
piperaquine (DHA-PQ) showed excellent treatment efficacy for uncomplicated malaria in …
piperaquine (DHA-PQ) showed excellent treatment efficacy for uncomplicated malaria in …