Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

The endothelial monolayer partitioning underlying tissue from blood components in the
vessel wall maintains tissue fluid balance and host defense through dynamically opening …

Microtubules undergo continual dynamic changes in mitotic cells as the mitotic spindle forms
and is broken down and in interphase cells where they play a central role in intracellular …

Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

Microtubules form from longitudinally and laterally assembling tubulin α–β dimers. The
assembly induces strain in tubulin, resulting in cycles of microtubule catastrophe and …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Novel N-benzylarylamide saderivatives were designed and synthesized, and their
antiproliferative activities were explored. Some of 51 target compounds exhibited potent …

Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …

Protein–protein interactions (PPIs) are fundamental to many biological processes that play
an important role in the occurrence and development of a variety of diseases. Targeting the …

Microtubules (MTs) are highly conserved polar polymers that are key elements of the
eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a …