Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features
The value of genome-wide over targeted driver analyses for predicting clinical outcomes of
cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic …
cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic …
BACH2: The Future of Induced T-Regulatory Cell Therapies
BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central
regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A …
regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A …
[HTML][HTML] Prognostic and chemotherapeutic response prediction by proliferation essential gene signature: Investigating POLE2 in bladder cancer progression and …
L Yu, N Lin, Y Ye, S Zhou, Y Xu, J Chen… - Journal of …, 2024 - ncbi.nlm.nih.gov
Background: Bladder cancer (BLCA) is the most common genitourinary malignancy.
Proliferation essential genes (PEGs) are crucial to the survival of cancer cells. This study …
Proliferation essential genes (PEGs) are crucial to the survival of cancer cells. This study …
[HTML][HTML] Identification of mutation gene prognostic biomarker in multiple myeloma through gene panel exome sequencing and transcriptome analysis in Chinese …
C Xie, L Zhong, J Luo, J Luo, Y Wu, S Zheng… - Computers in Biology …, 2023 - Elsevier
Background The 5-year survival rate of multiple myeloma (MM) in China is less than 40%,
with considerable individual heterogeneity. Gene mutations are important predictive …
with considerable individual heterogeneity. Gene mutations are important predictive …
circ_SPEF2 Regulates the Balance of Treg Cells by Regulating miR-16-5p/BACH2 in Lymphoma and Participates in the Immune Response
J Zhou, M Xu, ZZ Chen, LL Huang, ZL Wu… - Tissue Engineering and …, 2023 - Springer
BACKGROUND: This study aims to explore the potential mechanism of action of the newly
discovered hsa_circ_0128899 (circSPEF2) in diffuse large B-cell lymphoma (DLBCL) …
discovered hsa_circ_0128899 (circSPEF2) in diffuse large B-cell lymphoma (DLBCL) …
[HTML][HTML] Increased Frequency of Circulating Activated FOXP3+ Regulatory T Cell Subset in Patients with Chronic Lymphocytic Leukemia Is Associated with the …
Z Roškar, M Dreisinger, E Homšak, T Avčin, S Bevc… - Cancers, 2024 - mdpi.com
Simple Summary Patients with chronic lymphocytic leukemia (CLL) are more susceptible to
infections, which are also the most common cause of death in these patients. Previous …
infections, which are also the most common cause of death in these patients. Previous …
Single-cell analysis of a bi-clonal chronic lymphocytic leukemia reveals two clones with distinct gene expression pattern
M Dampmann, A Kibler, J von Tresckow… - Leukemia & …, 2024 - Taylor & Francis
Dual productive B-cell receptor (BCR) rearrangements have been repeatedly reported for
chronic lymphocytic leukemia (CLL), but the standard population-based PCR analyses …
chronic lymphocytic leukemia (CLL), but the standard population-based PCR analyses …
Insights into Breast Cancer Prognosis: A Differential Regulatory Network Approach to Identify Key Transcription Factor Biomarkers
F Akhoundi, F Akhoundi, M Ranjbarfard… - 2023 - researchsquare.com
Background. Breast cancer (BC) is the most common and aggressive type of cancer in
females, and exploring the mechanisms of disease progression is playing a crucial role in …
females, and exploring the mechanisms of disease progression is playing a crucial role in …
Exploring the prognostic necroptosis-related genes and underlying mechanism in sepsis using bioinformatics
J Liu, L Li, S He, X Zheng, D Zhu, G Kong, P Li - 2023 - researchsquare.com
Sepsis is a life-threatening disease due to a dysregulated host response to infection, with an
unknown regulatory mechanism for prognostic necroptosis-related genes (NRGs). Using …
unknown regulatory mechanism for prognostic necroptosis-related genes (NRGs). Using …
[图书][B] Temporal Dynamics of CLL Cells: Single-cell Analysis of Intra-Clonal Fractions Differing in Time Since Cell Birth
A Ng - 2022 - search.proquest.com
Chronic lymphocytic leukemia (CLL) is an incurable B-cell malignancy that is characterized
by remarkable clinical and molecular heterogeneity. Whereas certain patients with CLL can …
by remarkable clinical and molecular heterogeneity. Whereas certain patients with CLL can …