Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …

Aims SARS–CoV-2 causes severe respiratory syndrome (COVID-19) with high mortality due
to a direct cytotoxic viral effect and a severe systemic inflammation. We are herein …

Purpose Fibroblast activation protein (FAP) is a membrane-bound protease that has limited
expression in normal adult tissues but is highly expressed in the tumor microenvironment of …

Abstract Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4is) are oral anti-diabetic drugs
(OADs) for the treatment of type 2 diabetes mellitus (T2DM) through inhibiting the …

Abstract Val-boroPro (Talabostat, PT-100), a nonselective inhibitor of post-proline cleaving
serine proteases, stimulates mammalian immune systems through an unknown mechanism …

Summary CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation
antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal …

The tumor microenvironment (TME) surrounding tumor cells is a complex and highly
dynamic system that promotes tumorigenesis. Cancer-associated fibroblasts (CAFs) are key …

Purpose Fibroblast activation protein (FAP) is a cell membrane–bound serine peptidase,
overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound …

Abstract CD26/dipeptidyl peptidase (DPP) 4 is a membrane-bound protein found in many
cell types of the body, and a soluble form is present in body fluids. There is longstanding …

Highlights•The human proteasome is the second largest drug target class.•Few prototypic
proteases are standard tools for the discovery of novel inhibitors.•Peptide protease inhibitors …