Recent Advances in Catalytic Asymmetric Synthesis of Tertiary Alcohols via Nucleophilic Addition to Ketones
YL Liu, XT Lin - Advanced Synthesis & Catalysis, 2019 - Wiley Online Library
Chiral tertiary alcohols are an important class of organic compounds which have found wide
applications in both academia and industry. Therefore, various synthetic strategies towards …
applications in both academia and industry. Therefore, various synthetic strategies towards …
Asymmetric synthesis of chiral 3, 3-disubstituted oxindoles using isatin as starting material
GM Ziarani, R Moradi, N Lashgari - Tetrahedron: Asymmetry, 2015 - Elsevier
Disubstituted oxindoles with a stereogenic quaternary carbon center exist widely in various
natural products and biologically active compounds. Various strategies have been …
natural products and biologically active compounds. Various strategies have been …
Enantioselective construction of a congested quaternary stereogenic center in isoindolinones bearing three aryl groups via an organocatalytic formal Betti reaction
An efficient enantioselective formal Betti reaction between phenols and diaryl ketimines
generated in situ from isoindolinone alcohols is described. In a reaction catalyzed by a chiral …
generated in situ from isoindolinone alcohols is described. In a reaction catalyzed by a chiral …
Organocatalyzed Asymmetric Friedel‐Crafts Reactions: An Update
Abstract The Friedel‐Crafts alkylation (F‐CA) reaction is a special kind of carbon− carbon
bond formations, which is frequently being used for the formation of such bond in some …
bond formations, which is frequently being used for the formation of such bond in some …
[HTML][HTML] Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update
Oxindole scaffolds are prevalent in natural products and have been recognized as
privileged substructures in new drug discovery. Several oxindole-containing compounds …
privileged substructures in new drug discovery. Several oxindole-containing compounds …
Recent advances in the asymmetric catalytic synthesis of chiral 3-hydroxy and 3-aminooxindoles and derivatives: Medicinally relevant compounds
Several oxindole derivatives, of natural or synthetic origin, have been identified as
medicinally appealing compounds, with a plethora of bioactivities reported. Chiral 3-hydroxy …
medicinally appealing compounds, with a plethora of bioactivities reported. Chiral 3-hydroxy …
Catalytic enantioselective Friedel–Crafts reactions of naphthols and electron-rich phenols
The enantioselective Friedel–Crafts reaction is a powerful tool for the construction of
benzylic stereocenters in a stereodefined manner. Significant advances have already been …
benzylic stereocenters in a stereodefined manner. Significant advances have already been …
An unprecedented synthesis of axially chiral biaryls by rearrangement and aromatization of carbocations with central-to-axial conversion of chirality
Q Liu, XD Li, L Cheng, L Liu - Science China Chemistry, 2024 - Springer
The central-to-axial chirality conversion represents a fascinating class of chemical
processes consisting of the destruction of stereogenic centers and the simultaneous …
processes consisting of the destruction of stereogenic centers and the simultaneous …
Chiral Squaramide‐Catalyzed Enantioselective Decarboxylative Addition of β‐Keto Acids to Isatin Imines
J Kaur, A Kumari, VK Bhardwaj… - Advanced Synthesis & …, 2017 - Wiley Online Library
An efficient chiral squaramide‐catalyzed enantioselective decarboxylative addition reaction
of β‐keto acids to isatin imines has been developed. The reaction proceeds smoothly using …
of β‐keto acids to isatin imines has been developed. The reaction proceeds smoothly using …
Organocatalytic Enantioselective Friedel–Crafts Alkylation of 1‐Naphthol Derivatives and Activated Phenols with Ethyl Trifluoropyruvate
Abstract An organocatalytic enantioselective Friedel–Crafts alkylation of a series of
substituted 1‐naphthol derivatives and activated phenols with ethyl trifluoropyruvate …
substituted 1‐naphthol derivatives and activated phenols with ethyl trifluoropyruvate …