The opioid overdose crisis is driven by an intersecting set of social, structural, and economic
forces. Simulation models are a tool to help us understand and address thiscomplex …

Objectives The rapid increase in opioid overdose and opioid use disorder (OUD) over the
past 20 years is a complex problem associated with significant economic costs for …

Background Illicit opioid overdose continues to rise in North America and is a leading cause
of death. Mathematical modeling is a valuable tool to investigate the epidemiology of this …

Opioids have been shown to temporarily reduce the severity of pain when prescribed for
medical purposes. However, opioid analgesics can also lead to severe adverse physical …

Background: Illicit opioid overdose continues to rise in North America and is a leading cause
of death. Mathematical modeling is a valuable tool to investigate the epidemiology of this …

The opioid crisis is responsible for hundreds of thousands of deaths and trillions of dollars in
costs. A feature of this crisis is substantial underground transactions, leaving standard …