The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Metal neurotoxicity is a global health concern. This paper summarizes the evidence for
metal interactions with synaptic transmission and synaptic plasticity. Presynaptically metal …

Migraine with aura is a common but poorly understood sensory circuit disorder. Monogenic
models allow an opportunity to investigate its mechanisms, including spreading …

Lead (Pb) toxicity is still a major health problem associated with both environmental and
occupational exposure. Special attention is given to the neurotoxic effect of lead. Along with …

There is increasing evidence that toxic metals play a role in diseases of unknown etiology.
Their action is often mediated by membrane proteins, and in particular neurotransmitter …

Developmental exposure to either polycyclic aromatic hydrocarbons (PAHs) or heavy metals
has been shown to cause persisting and overlapping neurobehavioral effects in animal …

Astroglial cells have a variety of roles in the central nervous system (CNS), providing a
homeostasis for the proper functioning of neuronal cells. The classical view concerning the …

The desirable characteristics of lead-a malleable heavy metal resistant to corrosion-have
resulted in its extensive use, especially in building construction, for the past several …

Whether the multi-biological toxicity from lead exposure could be transferred to progeny has
not been clarified. In the present study, we explored the Caenorhabditis elegans to analyze …

Lead (Pb2+) is a potent neurotoxin that acts as a non-competitive, voltage-independent
antagonist of the NMDA receptor (NR) channel. Pb2+ action partially overlaps with that of …