Coenzyme Q10 and nicotinamide nucleotide transhydrogenase: Sentinels for mitochondrial hydrogen peroxide signaling
C Grayson, RJ Mailloux - Free Radical Biology and Medicine, 2023 - Elsevier
Mitochondria use hydrogen peroxide (H 2 O 2) as a mitokine for cell communication. H 2 O 2
output for signaling depends on its rate of production and degradation, both of which are …
output for signaling depends on its rate of production and degradation, both of which are …
[HTML][HTML] Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury
R Sun, M Peng, P Xu, F Huang, Y Xie, J Li… - Journal of …, 2020 - Springer
Background Inflammatory response has been recognized as a pivotal pathophysiological
process during cerebral ischemic stroke. NLRP3 inflammasome, involved in the regulation …
process during cerebral ischemic stroke. NLRP3 inflammasome, involved in the regulation …
Mitochondrial NAD(P)+ Transhydrogenase: From Molecular Features to Physiology and Disease
A Francisco, TR Figueira, RF Castilho - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: Proton-translocating NAD (P)+ transhydrogenase, also known as nicotinamide
nucleotide transhydrogenase (NNT), catalyzes a reversible reaction coupling the …
nucleotide transhydrogenase (NNT), catalyzes a reversible reaction coupling the …
Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies
Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/-
mouse studies having informed our understanding of GZMA's physiological function. We …
mouse studies having informed our understanding of GZMA's physiological function. We …
[HTML][HTML] CETP expression in bone-marrow-derived cells reduces the inflammatory features of atherosclerosis in hypercholesterolemic mice
CETP activity reduces plasma HDL-cholesterol concentrations, a correlate of an increased
risk of atherosclerotic events. However, our recent findings suggest that CETP expression in …
risk of atherosclerotic events. However, our recent findings suggest that CETP expression in …
Regulation of immune cell function by nicotinamide nucleotide transhydrogenase
T Regan, R Conway… - American Journal of …, 2022 - journals.physiology.org
Redox homeostasis is elemental for the normal physiology of all cell types. Cells use
multiple mechanisms to tightly regulate the redox balance. The onset and progression of …
multiple mechanisms to tightly regulate the redox balance. The onset and progression of …
[HTML][HTML] Tff3 deficiency protects against hepatic fat accumulation after prolonged high-fat diet
Trefoil factor 3 (Tff3) protein is a small secretory protein expressed on various mucosal
surfaces and is involved in proper mucosal function and recovery via various mechanisms …
surfaces and is involved in proper mucosal function and recovery via various mechanisms …
Novel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activity
HF Raposo, P Forsythe, B Chausse, JZ Castelli… - Metabolism, 2021 - Elsevier
Objective The systemic function of CETP has been well characterized. CETP plasma activity
reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here, we …
reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here, we …
A matter of food and substrain: obesogenic diets induce differential severity of cardiac remodeling in C57Bl/6J and C57Bl/6N substrains
L Cascarano, H Esfahani, P Michel… - Physiological …, 2024 - journals.physiology.org
The prevalence of metabolic syndrome in cardiac diseases such as heart failure with
preserved ejection fraction (HFpEF) prompts the scientific community to investigate its …
preserved ejection fraction (HFpEF) prompts the scientific community to investigate its …
Insights on how mitochondrial NAD(P)+ transhydrogenase plays a central metabolic role in proinflammatory macrophages
TR Figueira, RF Castilho - American Journal of Physiology …, 2022 - journals.physiology.org
TO THE EDITOR: We read with great interest the recent review article from Regan et al.(1),
which covered the experimental evidence regarding NAD (P) þ transhydrogenase (NNT) as …
which covered the experimental evidence regarding NAD (P) þ transhydrogenase (NNT) as …