Mitochondria use hydrogen peroxide (H 2 O 2) as a mitokine for cell communication. H 2 O 2
output for signaling depends on its rate of production and degradation, both of which are …

Background Inflammatory response has been recognized as a pivotal pathophysiological
process during cerebral ischemic stroke. NLRP3 inflammasome, involved in the regulation …

Significance: Proton-translocating NAD (P)+ transhydrogenase, also known as nicotinamide
nucleotide transhydrogenase (NNT), catalyzes a reversible reaction coupling the …

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/-
mouse studies having informed our understanding of GZMA's physiological function. We …

CETP activity reduces plasma HDL-cholesterol concentrations, a correlate of an increased
risk of atherosclerotic events. However, our recent findings suggest that CETP expression in …

Redox homeostasis is elemental for the normal physiology of all cell types. Cells use
multiple mechanisms to tightly regulate the redox balance. The onset and progression of …

Trefoil factor 3 (Tff3) protein is a small secretory protein expressed on various mucosal
surfaces and is involved in proper mucosal function and recovery via various mechanisms …

Objective The systemic function of CETP has been well characterized. CETP plasma activity
reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here, we …

The prevalence of metabolic syndrome in cardiac diseases such as heart failure with
preserved ejection fraction (HFpEF) prompts the scientific community to investigate its …

TO THE EDITOR: We read with great interest the recent review article from Regan et al.(1),
which covered the experimental evidence regarding NAD (P) þ transhydrogenase (NNT) as …