[HTML][HTML] Organophosphorus compounds and oximes: a critical review
F Worek, H Thiermann, T Wille - Archives of Toxicology, 2020 - Springer
Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population.
Treatment of OP poisoning is an ongoing challenge and burden for medical services …
Treatment of OP poisoning is an ongoing challenge and burden for medical services …
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents
G Mercey, T Verdelet, J Renou… - Accounts of chemical …, 2012 - ACS Publications
Since the September 11, 2001, terrorist attacks in the United States, the specter of a
chemical threat against civilian populations has renewed research interest in chemical …
chemical threat against civilian populations has renewed research interest in chemical …
[HTML][HTML] SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many
failures in living organism and ultimately in death. Organophosphorus compounds …
failures in living organism and ultimately in death. Organophosphorus compounds …
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
G Mercey, T Verdelet, G Saint-André, E Gillon… - Chemical …, 2011 - pubs.rsc.org
Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency
against acetylcholinesterase (AChE). Herein, we describe two first extremely promising …
against acetylcholinesterase (AChE). Herein, we describe two first extremely promising …
Development and structural modifications of cholinesterase reactivators against chemical warfare agents in last decade: a review
Organophosphate (OP) pesticides and nerve agents are responsible for suicidal and
accidental poisonings. The acute toxicity of nerve agents leads to progressive inhibition of …
accidental poisonings. The acute toxicity of nerve agents leads to progressive inhibition of …
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1, 3-diyl linkage—Preparation, in vitro screening and molecular docking
The treatment of organophosphorus (OP) poisoning consists of the administration of a
parasympatholytic agent (eg, atropine), an anticonvulsant (eg, diazepam) and an …
parasympatholytic agent (eg, atropine), an anticonvulsant (eg, diazepam) and an …
[HTML][HTML] Novel group of AChE reactivators—synthesis, in vitro reactivation and molecular docking study
The acetylcholinesterase (AChE) reactivators (eg, obidoxime, asoxime) became an
essential part of organophosphorus (OP) poisoning treatment, together with atropine and …
essential part of organophosphorus (OP) poisoning treatment, together with atropine and …
Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor
As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited
acetylcholinesterase (AChE), the majority of studies on these have been directed towards …
acetylcholinesterase (AChE), the majority of studies on these have been directed towards …
Oxime K203: a drug candidate for the treatment of tabun intoxication
L Gorecki, O Soukup, T Kucera, D Malinak, D Jun… - Archives of …, 2019 - Springer
For over 60 years, researchers across the world have sought to deal with poisoning by nerve
agents, the most toxic and lethal chemical weapons. To date, there is no efficient causal …
agents, the most toxic and lethal chemical weapons. To date, there is no efficient causal …
Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage–implications for early Myasthenia …
Inhibitors of acetylcholinesterase are compounds widely used in the treatment of various
diseases, such as Alzheimer's disease, glaucoma and Myasthenia gravis (MG). Compounds …
diseases, such as Alzheimer's disease, glaucoma and Myasthenia gravis (MG). Compounds …