Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited
self-renewal and their potential to differentiate to all cell lineages contained within the three …

For many years, stem cell metabolism was viewed as a byproduct of cell fate status rather
than an active regulatory mechanism; however, there is now a growing appreciation that …

Significance: It is increasingly clear that proline metabolism plays an important role in
metabolic reprogramming, not only in cancer but also in related fields such as aging …

Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing
energy, reducing equivalents and building blocks while several metabolites exert a …

Pluripotent stem cells have the ability to undergo self‐renewal and to give rise to all cells of
the tissues of the body. However, this definition has been recently complicated by the …

Cultured meat is meat for consumption produced in a more sustainable way. It involves cell
harvesting and expansion, differentiation into myotubes, construction into muscle fibres and …

The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in
the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic …

Mechanisms by which the proline regulatory axis modulates the cancer phenotype are being
revealed. Proline can be synthesized from glutamine as well as derived from collagen …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

Recent studies link changes in energy metabolism with the fate of pluripotent stem cells
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …