In eukaryotes, the spatiotemporal control of endolysosomal organelles is central to the
maintenance of homeostasis. By providing an interface between the cytoplasm and external …

Infections, such as that by the multiresistant opportunistic bacterial pathogen Pseudomonas
aeruginosa, may pose a serious health risk, especially on vulnerable patient populations …

The nematode intestine is the primary site for nutrient uptake and storage as well as the
synthesis of biomolecules; lysosome-related organelles known as gut granules are …

Heat shock can be a lethal stressor. Previously, we described a CUL-6/cullin-ring ubiquitin
ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular …

The biological roles of the autofluorescent lysosome-related organelles (“gut granules”) in
the intestinal cells of many nematodes, including Caenorhabditis elegans, have been shown …

Mechanisms of pathogen recognition in barrier tissues, which interface with both commensal
and virulent bacteria, are critical for health and not fully understood. Here, we discovered a …

3-Hydroxyanthranilic acid (3HAA) is a metabolite in the kynurenine pathway, a canonical
pathway in tryptophan catabolism. This metabolite extends lifespan in the roundworm …