PRAME updated: Diagnostic, prognostic, and therapeutic role in skin cancer

F Cassalia, A Danese, I Tudurachi, S Federico… - International Journal of …, 2024 - mdpi.com
Preferentially Expressed Antigen in Melanoma (PRAME), a member of the cancer/testis
antigen family, is central to the field of skin cancer diagnostics and therapeutics. As a …

PRAME immunohistochemistry as an ancillary test for the assessment of melanocytic lesions

C Lezcano, AA Jungbluth… - Surgical pathology …, 2021 - surgpath.theclinics.com
PRAME Immunohistochemistry as an Ancillary Test for the Assessment of Melanocytic
Lesions - Surgical Pathology Clinics Skip to Main Content Advertisement Surgical …

PRAME expression in cancer. A systematic immunohistochemical study of> 5800 epithelial and nonepithelial tumors

M Kaczorowski, M Chłopek, A Kruczak… - The American journal …, 2022 - journals.lww.com
Preferentially expressed antigen in melanoma (PRAME) is considered a useful marker in the
differential diagnosis between malignant melanoma and its melanocytic mimics. Recently …

Benefit and toxicity of programmed death‐1 blockade vary by ethnicity in patients with advanced melanoma: an international multicentre observational study

X Bai, AN Shoushtari, A Betof Warner… - British Journal of …, 2022 - academic.oup.com
Background Programmed cell death receptor‐1 (PD‐1) monotherapy is a standard treatment
for advanced cutaneous melanoma, but its efficacy and toxicity are defined in white …

The utility of PRAME staining in identifying malignant transformation of melanocytic nevi

ME Lohman, AJ Steen, RC Grekin… - Journal of Cutaneous …, 2021 - Wiley Online Library
Abstract Background PReferentially expressed Antigen in MElanoma (PRAME)
immunohistochemical (IHC) staining is used to aid melanoma diagnosis. PRAME …

The utility of PRAME immunohistochemistry in the evaluation of challenging melanocytic tumors

AK Alomari, AW Tharp, B Umphress… - Journal of Cutaneous …, 2021 - Wiley Online Library
Abstract Background PRAME (PReferentially expressed Antigen in Melanoma)
immunohistochemistry has demonstrated high specificity for unequivocal melanomas; …

Oncogenic cancer/testis antigens are a hallmarker of cancer and a sensible target for cancer immunotherapy

P Yang, M Meng, Q Zhou - Biochimica et Biophysica Acta (BBA)-Reviews …, 2021 - Elsevier
Increasing evidence shows that numerous cancer-testis antigens (CTAs) are uniquely
overexpressed in various types of cancer and most CTAs are oncogenic. Overexpression of …

PRAME expression in mucosal melanoma of the head and neck region

C Ricci, MV Altavilla, B Corti, E Pasquini… - The American Journal …, 2023 - journals.lww.com
PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed
in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool …

PRAME expression in cutaneous melanoma does not correlate with disease‐specific survival

O Parra, W Ma, Z Li, BN Coffing, K Linos… - Journal of …, 2023 - Wiley Online Library
Background Immunohistochemistry‐based protein biomarkers can provide useful prognostic
information in cutaneous melanoma. The independent prognostic value of Ki‐67 has been …

PRAME expression in melanocytic lesions of the nail

O Parra, K Linos, Z Li, S Yan - Journal of Cutaneous Pathology, 2022 - Wiley Online Library
Background Subungual melanoma can be diagnostically challenging. We evaluated the
potential of PReferentially expressed Antigen for MElanoma (PRAME) immunoreactivity for …