Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses …

Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …

The assembly and egress of herpes simplex virus (HSV) is a complicated multistage process
that involves several different cellular compartments and the activity of many viral and …

Here, we present a transformational approach to genome engineering of herpes simplex
virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomics tools. We …

Viruses encode for structural proteins that participate in virion formation and include capsid
and envelope proteins. In addition, viruses encode for an array of non-structural accessory …

All herpesviruses have mechanisms for passing through cell junctions, which exclude
neutralizing antibodies and offer a clear path to neighboring, uninfected cells. In the case of …

Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus associated with both B cell and
epithelial cell malignancies. EBV infection of B cells triggers activation of several signaling …

The alphaherpesvirus UL51 protein is a tegument component that interacts with the viral
glycoprotein E and functions at multiple steps in virus assembly and spread in epithelial …

During virion morphogenesis herpes simplex virus nucleocapsids transit from the
nucleoplasm to the cytoplasm, through a process called nuclear egress, where the final …

Alphaherpesviruses are zoonotic pathogens that can cause a variety of diseases in humans
and animals and severely damage health. Alphaherpesvirus infection is a slow and orderly …