Artificial intelligence and machine learning in computational nanotoxicology: unlocking and empowering nanomedicine

AV Singh, MHD Ansari, D Rosenkranz… - Advanced …, 2020 - Wiley Online Library
Advances in nanomedicine, coupled with novel methods of creating advanced materials at
the nanoscale, have opened new perspectives for the development of healthcare and …

Computational toxicology—a tool for early safety evaluation

C Merlot - Drug discovery today, 2010 - Elsevier
Although inappropriate pharmacokinetic properties were a major cause of attrition in the
1990s, safety issues are recognized as today's single largest cause of drug candidate …

Anti-Parkinson potential of hesperetin nanoparticles: in vivo and in silico investigations

PK Pasala, P Dsnbk, M Rudrapal… - Natural Product …, 2024 - Taylor & Francis
Parkinson's disease (PD) is characterised by the gradual demise of dopaminergic neurons.
In recent years, there has been significant interest in herbal treatments. In this study …

[图书][B] Introduction to toxicology

J Timbrell, FA Barile - 2023 - taylorfrancis.com
As with the previous editions, Introduction to Toxicology, Fourth Edition, continues to chart
the evolution of the field of toxicology, from the use of natural toxins by ancient tribes through …

Recent advances in trace analysis of pharmaceutical genotoxic impurities

DQ Liu, M Sun, AS Kord - Journal of pharmaceutical and biomedical …, 2010 - Elsevier
Genotoxic impurities (GTIs) in pharmaceuticals at trace levels are of increasing concerns to
both pharmaceutical industries and regulatory agencies due to their potentials for human …

Toward a comprehensive molecular design framework for reduced hazard

AM Voutchkova, TG Osimitz, PT Anastas - Chemical reviews, 2010 - ACS Publications
The history of chemistry has been one of understanding the properties and transformations
of matter. Perhaps the most important aspect of this understanding is the properties that …

Plant phenolics ferulic acid and p-coumaric acid inhibit colorectal cancer cell proliferation through EGFR down-regulation

N Roy, A Narayanankutty, PA Nazeem… - Asian Pacific Journal …, 2016 - journal.waocp.org
Background Colorectal cancer (CRC) or bowel cancer is one of the most important cancer
diseases, needing serious attention. The cell surface receptor gene human epidermal …

Anti-inflammatory activity of ginsenosides in LPS-stimulated RAW 264.7 cells

S Ahn, MH Siddiqi, HY Noh, YJ Kim, YJ Kim, CG Jin… - Science bulletin, 2015 - Springer
Ginsenosides, the main active constituents of Panax ginseng Meyer (P. ginseng), have
potential therapeutic effects. All tested ginsenosides except ginsenoside F1 have previously …

Integration of bioinformatics to biodegradation

PK Arora, H Bae - Biological Procedures Online, 2014 - Springer
Bioinformatics and biodegradation are two primary scientific fields in applied microbiology
and biotechnology. The present review describes development of various bioinformatics …

Toxicophore exploration as a screening technology for drug design and discovery: techniques, scope and limitations

PK Singh, A Negi, PK Gupta, M Chauhan… - Archives of toxicology, 2016 - Springer
Toxicity is a common drawback of newly designed chemotherapeutic agents. With the
exception of pharmacophore-induced toxicity (lack of selectivity at higher concentrations of a …