Salmonella infection causes morbidity and mortality throughout the world with the host
immune response varying depending on whether the infection is acute and limited, or …

Originally described over a decade ago as a T cell transcription factor regulating T helper 1
cell lineage commitment, T-bet is now recognized as having an important role in many cells …

Inborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease.
We report a patient with mycobacterial disease due to inherited deficiency of the …

T‐bet and Eomes are T‐box transcription factors that drive the differentiation and function of
cytotoxic lymphocytes such as NK cells. Their DNA‐binding domains are highly similar …

The activation of immune-defense mechanisms in response to a microbial attack must be
robust and appropriately tailored to fight particular types of pathogens. Infection with …

Coccidiosis, a major intestinal parasitic disease of poultry, induces a cell-mediated immune
response against the etiologic agent of the disease, Eimeria. In the current study, the …

Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human
typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic …

Host-adapted strains of Salmonella enterica cause systemic infections and have the ability
to persist systemically for long periods of time and pose significant public-health problems …

CD4+ T helper cells regulate appropriate cellular and humoral immune responses to a wide
range of pathogens and get involved in many diseases progress. The balance of the earliest …

The identification of T-bet as a key transcription factor associated with the development of
IFNγ-producing CD4+ T cells predicted a crucial role for T-bet in cell-mediated immunity and …