Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

Understanding the changes in the brain which occur in the transition from normal to
addictive behavior has major implications in public health. Here we postulate that while …

The rat prelimbic prefrontal cortex and nucleus accumbens core are critical for initiating
cocaine seeking. In contrast, the neural circuitry responsible for inhibiting cocaine seeking …

Long-term changes in glutamate transmission in the nucleus accumbens core (NAcore)
contribute to the reinstatement of drug seeking after extinction of cocaine self-administration …

This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens
(NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental …

Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and heroin are a
significant burden on healthcare systems all over the world. The positive reinforcing …

A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …

Activation of medium spiny neurons (MSNs) of the nucleus accumbens is critical for goal-
directed behaviors including cocaine seeking. Studies in cocaine-experienced rodents have …

Drug addiction remains a key biomedical challenge facing current neuroscience research. In
addition to neural mechanisms, the focus of the vast majority of studies to date, astrocytes …

The glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmPFC) and
projecting to the nucleus accumbens (NAc) core is a critical component of the reward …