As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

During migration, cells often squeeze through small constrictions, requiring extensive
deformation. We hypothesized that nuclear deformation associated with such confined …

Layers of genome organization are becoming increasingly better characterized, but less is
known about how these structures respond to perturbation or shape changes. Low-salt …

Biologists have the capability to edit a genome at the nanometer scale and then observe
whether or not the edit affects the structure of a developing organ or organism at the …

The cancer cell nucleus deforms as it invades the interstitial spaces in tissues and the tumor
microenvironment. While alteration of the chromatin structure in a deformed nucleus is …

The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and
consists of lamin filaments and associated proteins. Lamins are type V intermediate filament …

Nuclear deformability plays a critical role in cell migration. During this process, the
remodeling of internal components of the nucleus has a direct impact on DNA damage and …

Nowadays, it is an established concept that the capability to reach a specialised cell identity
via differentiation, as in the case of multi-and pluripotent stem cells, is not only determined …

Cell migration plays a pivotal role in various biological processes including cancer
dissemination and successful metastasis, where the role of mechanical signals is …