Abstract Poly (ADP-ribose) polymerases (PARPs) are involved in the regulation of many
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …

Poly (ADP-ribose) polymerases (PARPs) are defined as cell signaling enzymes that catalyze
the transfer of ADP-ribose units from NAD+ to a number of acceptor proteins. PARP-1, the …

Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in clinical
trials as cancer therapeutics, yet the specificity of many of these compounds is unknown …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …

Major advances have recently defined functions for human mono-ADP-ribosylating PARP
enzymes (mono-ARTs), also opening up potential applications for targeting them to treat …

The role of NF-κB in the expression of inflammatory genes and its participation in the overall
inflammatory process of chronic diseases and acute tissue injury are well established. We …

Poly (ADP-ribose) polymerases (PARPs) are enzymes that are able to catalyze the transfer
of ADP-ribose units from NAD to substrate proteins and are particularly abundant in cell …

To obtain further information on time course and mechanisms of cell death after poly (ADP-
ribose) polymerase-1 (PARP-1) hyperactivation, we used HeLa cells exposed for 1 h to the …

Epigenetics is concerned about heritable changes in gene expression without alteration of
the coding sequence. Epigenetic modification of chromatin includes methylation of genomic …

Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in DNA repair, replication, transcription and cell death. In this paper, the main features of this …