CXCL13 and its receptor CXCR5 in cancer: inflammation, immune response, and beyond

MG Kazanietz, M Durando, M Cooke - Frontiers in endocrinology, 2019 - frontiersin.org
It is well-established that the chemokine CXC motif ligand 13 (CXCL13) and its receptor, the
G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory …

Angiogenesis and anti-angiogenic treatment in prostate cancer: mechanisms of action and molecular targets

E Ioannidou, M Moschetta, S Shah, JS Parker… - International journal of …, 2021 - mdpi.com
Prostate cancer (PC) is the most common cancer in men and the second leading cause of
cancer-related death worldwide. Many therapeutic advances over the last two decades have …

[HTML][HTML] The role of cyclooxygenase-2 in colorectal cancer

J Sheng, H Sun, FB Yu, B Li, Y Zhang… - International journal of …, 2020 - ncbi.nlm.nih.gov
Colorectal cancer is the third common cancer in this world, accounting for more than 1
million cases each year. However, detailed etiology and mechanism of colorectal cancer …

Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity

M Cooke, MG Kazanietz - Science Signaling, 2022 - science.org
Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

The PTEN conundrum: how to target PTEN-deficient prostate cancer

DJ Turnham, N Bullock, MS Dass, JN Staffurth… - Cells, 2020 - mdpi.com
Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …

[PDF][PDF] The inflammatory profile of the tumor microenvironment, orchestrated by cyclooxygenase-2, promotes epithelial-mesenchymal transition

F Gómez-Valenzuela, E Escobar… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) corresponds to a complex and dynamic interconnection
between the extracellular matrix and malignant cells and their surrounding stroma …

Inflammation and NF-κB signaling in prostate cancer: Mechanisms and clinical implications

J Staal, R Beyaert - Cells, 2018 - mdpi.com
Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …

COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers

P Rodrigues, H Bangali, A Hammoud, YF Mustafa… - Medical Oncology, 2024 - Springer
Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-
2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion …

Chronic exposure to microcystin-LR increases the risk of prostate cancer and induces malignant transformation of human prostate epithelial cells

C Pan, L Zhang, X Meng, H Qin, Z Xiang, W Gong… - Chemosphere, 2021 - Elsevier
Abstract Microcystins-LR (MC-LR) acts as a possible carcinogen for humans and causes a
serious risk to public environmental health. The current study aimed to evaluate the …

Nanoliposomal formulation encapsulating celecoxib and genistein inhibiting COX-2 pathway and Glut-1 receptors to prevent prostate cancer cell proliferation

J Tian, F Guo, Y Chen, Y Li, B Yu, Y Li - Cancer Letters, 2019 - Elsevier
Globally, prostate cancer remains a challenging health burden for men as it is the second
leading cause of cancer death in men and about one in nine will be diagnosed with prostate …