Findings over the past decade have identified aberrant activation of the ETS transcription
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number …

Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the
oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but …

Abstract In the United States, prostate cancer (PCa) is the most commonly diagnosed non-
cutaneous cancer in males and the second leading cause of cancer-related death for men …

Luminal cells are believed to be the cells of origin for human prostate cancer, because the
disease is characterized by luminal cell expansion and the absence of basal cells. Yet …

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …

Recurrent fusions of ETS genes are considered driving mutations in a diverse array of
cancers, including Ewing's sarcoma, acute myeloid leukemia, and prostate cancer. We …

The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is often
altered in prostate cancer. To determine the prevalence and clinical significance of the …