Copper metabolism in cell death and autophagy

Q Xue, R Kang, DJ Klionsky, D Tang, J Liu, X Chen - Autophagy, 2023 - Taylor & Francis
Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications

G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

Targeting copper in cancer therapy: 'Copper That Cancer'

D Denoyer, S Masaldan, S La Fontaine, MA Cater - Metallomics, 2015 - academic.oup.com
Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …

[HTML][HTML] Copper in cancer: from pathogenesis to therapy

D Guan, L Zhao, X Shi, X Ma, Z Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
One of the basic trace elements for the structure and metabolism of human tissue is copper.
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …

Mitochondrial copper in human genetic disorders

NM Garza, AB Swaminathan, KP Maremanda… - Trends in Endocrinology …, 2023 - cell.com
Copper is an essential micronutrient that serves as a cofactor for enzymes involved in
diverse physiological processes, including mitochondrial energy generation. Copper enters …

Metabolism and functions of copper in brain

IF Scheiber, JFB Mercer, R Dringen - Progress in neurobiology, 2014 - Elsevier
Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Dissecting copper biology and cancer treatment:'Activating Cuproptosis or suppressing Cuproplasia'

Y Yang, M Li, G Chen, S Liu, H Guo, X Dong… - Coordination Chemistry …, 2023 - Elsevier
Copper, an essential micronutrient, controls multiple fundamental processes throughout all
forms of life, such as respiration, cell proliferation and neurotransmitter biosynthesis. High …

Non-traditional stable isotopes: retrospective and prospective

FZ Teng, N Dauphas… - Reviews in mineralogy …, 2017 - pubs.geoscienceworld.org
Traditional stable isotope geochemistry involves isotopes of light elements such as H, C, N,
O, and S, which are measured predominantly by gas-source mass spectrometry (Valley et al …

Function and regulation of human copper-transporting ATPases

S Lutsenko, NL Barnes, MY Bartee… - Physiological …, 2007 - journals.physiology.org
Copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B are evolutionarily
conserved polytopic membrane proteins with essential roles in human physiology. The Cu …

Targeting cuproplasia and cuproptosis in cancer

D Tang, G Kroemer, R Kang - Nature Reviews Clinical Oncology, 2024 - nature.com
Copper, an essential trace element that exists in oxidized and reduced forms, has pivotal
roles in a variety of biological processes, including redox chemistry, enzymatic reactions …