Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions
responsible for memory and learning. It plays a key role in modulating rapid changes in …

G-protein-coupled receptors (GPCRs) represent one of the largest gene families in the
animal genome. These receptors can be classified into several groups based on the …

The capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel
expressed on nociceptive sensory neurons that responds to noxious thermal and chemical …

Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …

In 1991 a new type of G-protein-coupled receptor (GPCR) was cloned, the type 1a
metabotropic glutamate (mGlu) receptor, which, despite possessing the defining seven …

The regulation of glutamate-mediated excitatory neurotransmission has a critical role in
many aspects of behaviour. Great effort has gone into understanding the signal transduction …

Metabotropic glutamate (mglu) receptors are implicated in the regulation of many
physiological and pathological processes in the CNS, including synaptic plasticity, learning …

A-type potassium currents are important determinants of neuronal excitability. In spinal cord
dorsal horn neurons, A-type currents are modulated by extracellular signal-regulated …