Necrotizing enterocolitis: It's not all in the gut

AL Meister, KK Doheny… - Experimental biology and …, 2020 - journals.sagepub.com
Necrotizing enterocolitis is the leading cause of death due to gastrointestinal disease in
preterm neonates, affecting 5–12% of neonates born at a very-low birth weight. Necrotizing …

Necrotizing enterocolitis: Pathophysiology from a historical context

D Hackam, M Caplan - Seminars in pediatric surgery, 2018 - Elsevier
Necrotizing enterocolitis (NEC) continues to afflict approximately 7% of preterm infants born
weighing less than 1500 g, though recent investigations have provided novel insights into …

Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants

MC Collado, M Cernada, J Neu, G Pérez-Martínez… - Pediatric …, 2015 - nature.com
The role of microbial colonization is indispensable for keeping a balanced immune
response in life. However, the events that regulate the establishment of the microbiota, their …

Human milk oligosaccharides to prevent gut dysfunction and necrotizing enterocolitis in preterm neonates

SB Bering - Nutrients, 2018 - mdpi.com
This review focuses on the evidence for health benefits of human milk oligosaccharides
(HMOs) for preterm infants to stimulate gut adaptation and reduce the incidence of …

Potential benefits of bovine colostrum in pediatric nutrition and health

PT Sangild, C Vonderohe, V Melendez Hebib… - Nutrients, 2021 - mdpi.com
Bovine colostrum (BC), the first milk produced from cows after parturition, is increasingly
used as a nutritional supplement to promote gut function and health in other species …

Current research on the epidemiology, pathogenesis, and management of necrotizing enterocolitis

S Eaton, CM Rees, NJ Hall - Neonatology, 2017 - karger.com
Despite decades of research on necrotizing enterocolitis, we still do not fully understand the
pathogenesis of the disease, or how to prevent or how to treat it. However, as a result of …

Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis

P Lu, CP Sodhi, DJ Hackam - Pathophysiology, 2014 - Elsevier
Toll-like receptors (TLRs) are a structurally related family of molecules that respond to a
wide variety of endogenous and exogenous ligands, and which serve as important …

The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis

Z Hodzic, AM Bolock, M Good - Frontiers in pediatrics, 2017 - frontiersin.org
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal disease of
prematurity. Although the precise cause is not well understood, the main risk factors thought …

Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis

B Li, C Lee, JS O'Connell, L Antounians, N Ganji… - Cell death & …, 2020 - nature.com
Necrotizing enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm
neonates and causing high morbidity, high mortality, and huge costs for the family and …

A review on early gut maturation and colonization in pigs, including biological and dietary factors affecting gut homeostasis

N Everaert, S Van Cruchten, B Weström… - Animal feed science and …, 2017 - Elsevier
During the prenatal, neonatal and post-weaning periods, the mammalian gastrointestinal
tract undergoes various morphological and physiological changes alongside with an …