Context: Autoantibodies that are reactive to islet antigens are present at the time of
diagnosis in most patients with type 1 diabetes. Additionally, approximately 10% of …

The histopathology of type 1 diabetes is defined by a decreased β-cell mass in association
with insulitis, a characteristic lymphocytic infiltration limited to the islets of Langerhans and …

OBJECTIVE This study investigated the temporal dynamics of pancreas volume and
microstructure in children and adolescents with recent-onset type 1 diabetes (T1D) and …

Context: Pancreatic atrophy is common in longstanding type 1 diabetes, but there are limited
data concerning pancreas size at diagnosis. Objective: Our objective was to determine …

OBJECTIVE Fulminant type 1 diabetes is characterized by the rapid onset of severe
hyperglycemia and ketoacidosis, with subsequent poor prognosis of diabetes complications …

OBJECTIVE Pancreas size is reduced in patients at type 1 diabetes onset and in
autoantibody (AAB)-positive donors without diabetes. We sought to determine whether …

Human type 1 diabetes (T1D) is considered to be an autoimmune disease, with CD8+ T-cell-
mediated cytotoxicity being directed against the insulin-producing beta cells, leading to a …

Objectives Imaging studies are expected to produce reliable information regarding the size
and fat content of the pancreas. However, the available studies have produced inconclusive …

Limitations in islet β-cell transplantation as a therapeutic option for type 1 diabetes have
prompted renewed interest in islet regeneration as a source of new islets. In this study we …

Context The cellular basis of persistent β-cell function in type 1 diabetes (T1D) remains
enigmatic. No extensive quantitative β-cell studies of T1D pancreata have been performed …