Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and
BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for …

The ATM gene is mutated in the syndrome, ataxia-telangiectasia (AT), which is
characterized by predisposition to cancer. Patients with AT have an elevated risk of breast …

Abstract Abstract Background, Breast cancer (BC) is one of the leading causes of cancer
related deaths in Iran. This high ratio of mortality had a rising trend during the recent years …

Ataxia telangiectasia mutated (ATM) is a key gene in DNA double-strand break (DSB), and
therefore, most of its disabling genetic alterations play an important initiative role in many …

Background Ovarian malignancies are often diagnosed in advanced stage and at the same
time resistance to treatment, both intrinsic and developed during treatment, is sometimes …

Background Emerging evidence suggests that ataxia telangiectasia-mutated (ATM) is
involved in numerous damage repair signaling pathways and cell-cycle checkpoints …

Background While a range of common genetic variants have been identified to be
associated with risk of sporadic breast cancer in several Western studies, little is known …

Historically, clinicians made observations in their clinical practice regarding certain
associations of specific central nervous system (CNS) tumors and other clinical findings …

BACKGROUND Although circulating tumor cells (CTCs) have been the focus of
consideration for a decade, a categorized cell-based diagnostic strategy is unavailable. The …

It was previously reported that tumour samples had shorter telomeres than the surrounding
normal tissue. Hereby, the initial sign of correlation between malignant tissue and telomere …