The transportome of the malaria parasite

RE Martin - Biological Reviews, 2020 - Wiley Online Library
Membrane transport proteins, also known as transporters, control the movement of ions,
nutrients, metabolites, and waste products across the membranes of a cell and are central to …

[HTML][HTML] Comparative application of BioID and TurboID for protein-proximity biotinylation

DG May, KL Scott, AR Campos, KJ Roux - Cells, 2020 - mdpi.com
BioID is a well-established method for identifying protein–protein interactions and has been
utilized within live cells and several animal models. However, the conventional labeling …

Multi-omics approaches to improve malaria therapy

M Zhou, A Varol, T Efferth - Pharmacological Research, 2021 - Elsevier
Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …

[HTML][HTML] Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID

Z Na, X Dai, SJ Zheng, CJ Bryant, KH Loh, H Su, Y Luo… - Molecular cell, 2022 - cell.com
Proteogenomic identification of translated small open reading frames has revealed
thousands of previously unannotated, largely uncharacterized microproteins, or …

[HTML][HTML] Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles

J Janouškovec, GG Paskerova, TS Miroliubova… - Elife, 2019 - elifesciences.org
The phylum Apicomplexa comprises human pathogens such as Plasmodium but is also an
under-explored hotspot of evolutionary diversity central to understanding the origins of …

Reconstruction of plastid proteomes of apicomplexans and close relatives reveals the major evolutionary outcomes of cryptic plastids

V Mathur, ED Salomaki, KC Wakeman… - Molecular Biology …, 2023 - academic.oup.com
Apicomplexans and related lineages comprise many obligate symbionts of animals; some of
which cause notorious diseases such as malaria. They evolved from photosynthetic …

[HTML][HTML] Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase

A Seidi, LS Muellner-Wong, E Rajendran, ET Tjhin… - Elife, 2018 - elifesciences.org
The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full
complement of proteins that localize to this organelle has not been defined. Here we …

Metabolic quirks and the colourful history of the Euglena gracilis secondary plastid

AMG Novák Vanclová, M Zoltner, S Kelly… - New …, 2020 - Wiley Online Library
Euglena spp. are phototrophic flagellates with considerable ecological presence and
impact. Euglena gracilis harbours secondary green plastids, but an incompletely …

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

M Okada, K Rajaram, RP Swift, A Mixon, JA Maschek… - Elife, 2022 - elifesciences.org
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle
in Plasmodium falciparum malaria parasites and is required for prenylation-dependent …

Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite

P Qian, X Wang, CQ Zhong, J Wang, M Cai… - Elife, 2022 - elifesciences.org
Malaria is caused by infection of the erythrocytes by the parasites Plasmodium. Inside the
erythrocytes, the parasites multiply via schizogony, an unconventional cell division mode …