The thioredoxin system as a therapeutic target in human health and disease

DFD Mahmood, A Abderrazak, K El Hadri… - Antioxidants & redox …, 2013 - liebertpub.com
The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …

Extracellular CIRP (eCIRP) and inflammation

M Aziz, M Brenner, P Wang - Journal of leukocyte biology, 2019 - academic.oup.com
Cold-inducible RNA-binding protein (CIRP) was discovered 2 decades ago while studying
the mechanism of cold stress adaptation in mammals. Since then, the role of intracellular …

Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold

X Zhu, C Bührer, S Wellmann - Cellular and molecular life sciences, 2016 - Springer
Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are
two evolutionarily conserved RNA-binding proteins that are transcriptionally upregulated in …

Exosome-derived CIRP: An amplifier of inflammatory diseases

J Han, Y Zhang, P Ge, TC Dakal, H Wen… - Frontiers in …, 2023 - frontiersin.org
Cold-inducible RNA-binding protein (CIRP) is an intracellular stress-response protein and a
type of damage-associated molecular pattern (DAMP) that responds to various stress …

The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational …

F De Leeuw, T Zhang, C Wauquier, G Huez… - Experimental cell …, 2007 - Elsevier
The cold-inducible RNA-binding protein (CIRP) is a nuclear 18-kDa protein consisting of an
amino-terminal RNA Recognition Motif (RRM) and a carboxyl-terminal domain containing …

Cold‐inducible RNA binding protein in cancer and inflammation

DA Lujan, JL Ochoa, RS Hartley - Wiley Interdisciplinary …, 2018 - Wiley Online Library
RNA binding proteins (RBPs) play key roles in RNA dynamics, including subcellular
localization, translational efficiency and metabolism. Cold‐inducible RNA binding protein …

Recent progress in the research of cold-inducible RNA-binding protein

P Zhong, H Huang - Future science OA, 2017 - Taylor & Francis
Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein which can be induced
after exposure to a moderate cold-shock in different species ranging from amphibians to …

Identification of G-quadruplex-binding protein from the exploration of RGG motif/G-quadruplex interactions

ZL Huang, J Dai, WH Luo, XG Wang… - Journal of the …, 2018 - ACS Publications
The arginine/glycine-rich region termed the RGG domain is usually found in G-quadruplex
(G4)-binding proteins and is important in G4–protein interactions. Studies on the binding …

Long noncoding RNAs and RNA‐binding proteins in oxidative stress, cellular senescence, and age‐related diseases

C Kim, D Kang, EK Lee, JS Lee - Oxidative Medicine and …, 2017 - Wiley Online Library
Cellular senescence is a complex biological process that leads to irreversible cell‐cycle
arrest. Various extrinsic and intrinsic insults are associated with the onset of cellular …

Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers

K Masuda, Y Kuwano - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
Gene expression patterns in cancer cells are strongly influenced by posttranscriptional
mechanisms. RNA‐binding proteins (RBPs) play key roles in posttranscriptional gene …