The role of artificial intelligence in early cancer diagnosis
B Hunter, S Hindocha, RW Lee - Cancers, 2022 - mdpi.com
Simple Summary Diagnosing cancer at an early stage increases the chance of performing
effective treatment in many tumour groups. Key approaches include screening patients who …
effective treatment in many tumour groups. Key approaches include screening patients who …
Inflammatory microenvironment remodelling by tumour cells after radiotherapy
M McLaughlin, EC Patin, M Pedersen, A Wilkins… - Nature Reviews …, 2020 - nature.com
The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …
about cancer treatment. Even so, for most types of cancer, only a minority of patients …
[HTML][HTML] Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies
DM Wolf, C Yau, J Wulfkuhle, L Brown-Swigart… - Cancer Cell, 2022 - cell.com
Using pre-treatment gene expression, protein/phosphoprotein, and clinical data from the I-
SPY2 neoadjuvant platform trial (NCT01042379), we create alternative breast cancer …
SPY2 neoadjuvant platform trial (NCT01042379), we create alternative breast cancer …
Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways
Y Zhang, F Chen, DS Chandrashekar… - Nature …, 2022 - nature.com
Mass-spectrometry-based proteomic data on human tumors—combined with corresponding
multi-omics data—present opportunities for systematic and pan-cancer proteogenomic …
multi-omics data—present opportunities for systematic and pan-cancer proteogenomic …
Signatures of copy number alterations in human cancer
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
A pan-cancer compendium of chromosomal instability
Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and
rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of …
rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of …
Genetic insights into biological mechanisms governing human ovarian ageing
Reproductive longevity is essential for fertility and influences healthy ageing in women,, but
insights into its underlying biological mechanisms and treatments to preserve it are limited …
insights into its underlying biological mechanisms and treatments to preserve it are limited …
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining
DA Ramsden, J Carvajal-Garcia… - Nature reviews Molecular …, 2022 - nature.com
Cellular pathways that repair chromosomal double-strand breaks (DSBs) have pivotal roles
in cell growth, development and cancer. These DSB repair pathways have been the target of …
in cell growth, development and cancer. These DSB repair pathways have been the target of …
Cancer aneuploidies are shaped primarily by effects on tumour fitness
J Shih, S Sarmashghi, N Zhakula-Kostadinova… - Nature, 2023 - nature.com
Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …
State-of-the-art strategies for targeting the DNA damage response in cancer
Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …
damage response (DDR) and/or increased replication stress. These alterations promote the …