Gamma aminobutyric acid (GABA) is a non-proteinogenic amino acid and neurotransmitter
that is produced in the islet at levels as high as in the brain. GABA is synthesized by the …

Background: Diabetes mellitus (DM) is an endocrine disorder characterized by
hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an …

Aims/hypothesis Islet autoimmunity usually starts with the appearance of autoantibodies
against either insulin (IAA) or GAD65 (GADA). This categorises children with preclinical type …

Autoantibodies are currently the most robust biomarkers of type 1 diabetes and are
frequently used to establish entry criteria for the participation of genetically at-risk individuals …

Defects in brain energy metabolism and proteopathic stress are implicated in age-related
degenerative neuronopathies, exemplified by Alzheimer's disease (AD) and Parkinson's …

Aims/hypothesis γ-Aminobutyric acid (GABA) is a signalling molecule in the interstitial space
in pancreatic islets. We examined the expression and function of the GABA signalling …

Islet autoantigens associated with autoimmune type 1 diabetes (T1D) are expressed in
pancreatic β cells, although many show wider patterns of expression in the neuroendocrine …

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (γ-aminobutyric
acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet …

Preclinical studies show that GABA exerts anti-diabetic effects in rodent models of type 1
diabetes. Because little is known about its absorption and effects in humans, we investigated …

Epilepsy is a prevalent and frequently devastating neurological disorder defined by
recurring spontaneous seizures caused by aberrant electrical activity in the brain. Over ten …